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Aprotinin from bovine lung

SIGMA/A1153 - lyophilized powder, 3-8 TIU/mg solid

Synonym: Trasylol; Trypsin inhibitor (basic)

CAS Number: 9087-70-1
Empirical Formula (Hill Notation): C284H432N84O79S7
Molecular Weight: 6511.44
EC Number: 232-994-9
MDL Number: MFCD00130541
Linear Formula: C284H432N84O79S7
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-A1153-1MG 1 mg
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45-A1153-5MG 5 mg
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45-A1153-10MG 10 mg
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45-A1153-25MG 25 mg
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45-A1153-100MG 100 mg
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45-A1153-250MG 250 mg
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While aprotinin and bovine pancreatic trypsin inhibitor (BPTI) are the same protein sequence, the term aprotinin is typically used when describing the protein derived from bovine lung. Aprotinin is a single peptide chain with three disulfide bonds. Molecular Weight: ~6511


form lyophilized powder
mol wt mol wt ~6,500
solubility H2O: ≥5 mg/mL
storage temp. 2-8°C
Application: Aprotinin is largely used as an inhibitor of trypsin.
Biochem/physiol Actions: Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.
Frequently Asked Questions: Frequently Asked Questions  are available for this Product.
Packaging: 1, 5 mg in glass bottle
Packaging: 10, 25, 100, 250 mg in poly bottle
Preparation Note: This product is a lyophilized powder with activity of 3-8 TIU/mg of solid powder. Aprotinin is freely soluble in water (>10 mg/mL) and in aqueous buffers of low ionic strengths. Dilute solutions tend to be less stable than concentrated ones, though solution stability also depends on pH. Aprotinin is relatively stable against denaturation - only thermolysin has been found capable of degrading it at 60-80°C. Sterilizaiton of Aprotinin can be achieved through filtration by a 0.2 μm filter.
Unit Definition: One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS YN5080000
Storage Temp. 2-8°C
UNSPSC 12352202

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