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Trimethoprim

SIGMA/92131 - ≥99.0% (HPLC)

Synonym: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; NSC 106568

CAS Number: 738-70-5
Empirical Formula (Hill Notation): C14H18N4O3
Molecular Weight: 290.32
EC Number: 212-006-2
MDL Number: MFCD00036761
Linear Formula: C14H18N4O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-92131-1G 1 g
 $50.10
1/EA		 Add To Favorites
45-92131-5G 5 g
 $174.00
1/EA		 Add To Favorites
45-92131-25G 25 g
 $688.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
  mycobacteria
assay ≥99.0% (HPLC)
biological source synthetic
color white to light yellow
form powder
InChI 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChI key IEDVJHCEMCRBQM-UHFFFAOYSA-N
mode of action DNA synthesis | interferes
  enzyme | inhibits
mp ≥199.0 °C
Quality Level 200 
SMILES string COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
storage temp. 2-8°C
Application: Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Application: Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis and mechanism of resistance studies in Haemophilus influenzae .
Biochem/physiol Actions: Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Biochem/physiol Actions: Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
General description: Chemical structure: pyrimidine
Other Notes: Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.
Packaging: 1g,5g,25g
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P264 - P270 - P301 + P312 - P501
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥99.0% (HPLC)
mp ≥199.0 °C
Storage Temp. 2-8°C
UNSPSC 51285203

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