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Tetracycline

SIGMA/87128 - 98.0-102.0% (HPLC)

Synonym: Tetracycline HCL; Tetracycline Monohydrochloride

CAS Number: 60-54-8
Empirical Formula (Hill Notation): C22H24N2O8 · xH2O
Molecular Weight: 444.43 (anhydrous basis)
EC Number: 200-481-9
MDL Number: MFCD00151232
Linear Formula: C22H24N2O8 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-87128-25G 25 g
 $73.20
1/EA		 Add To Favorites
45-87128-100G 100 g
 $244.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
assay 98.0-102.0% (HPLC)
biological source synthetic
color faint yellow to dark yellow
form powder or crystals
InChI 1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
InChI key OFVLGDICTFRJMM-WESIUVDSSA-N
mode of action protein synthesis | interferes
mp 172-174 °C (dec.)
Quality Level 200 
SMILES string CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
storage temp. 2-8°C
Biochem/physiol Actions: Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
General description: Chemical structure: tetracycline
Other Notes: Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place.
Packaging: 25g, 100g
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P264 - P270 - P301 + P312 - P501
Hazard Codes Xn
Risk Statements 22
Safety Statements 22-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity 98.0-102.0% (HPLC)
mp 172-174 °C (dec.)
Storage Temp. 2-8°C
UNSPSC 51284017

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