Spermine tetrahydrochloride
SIGMA/85610 - ≥99.0% (AT), powder or crystals
Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
CAS Number: 306-67-2
Empirical Formula (Hill Notation): C10H26N4 · 4HCl
Molecular Weight: 348.18
EC Number: 206-189-8
MDL Number: MFCD00012914
Linear Formula: C10H26N4 · 4HCl
Product Type: Chemical
| assay | ≥99.0% (AT) |
| biological source | microbial |
| synthetic | |
| form | powder or crystals |
| InChI | 1S/C10H26N4.4ClH/c11-5-3- |
| InChI key | XLDKUDAXZWHPFH-UHFFFAOYSA |
| mp | 310-311 °C (dec.) (lit.) |
| Quality Level | 300 ![]() |
| SMILES string | Cl.Cl.Cl.Cl.NCCCNCCCCNCCC |
| solubility | H2O: 0.1 g/mL, clear |
| storage temp. | room temp |
| Application: | Used to precipitate DNA from low salt aqueous buffers. |
| Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Symbol | GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.0% (AT) |
| mp | 310-311 °C (dec.) (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |


