Spermine tetrahydrochloride
SIGMA/85605 - BioUltra, Molecular Biology, ≥99.5% (AT)
Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
CAS Number: 306-67-2
Empirical Formula (Hill Notation): C10H26N4 · 4HCl
Molecular Weight: 348.18
EC Number: 206-189-8
MDL Number: MFCD00012914
Linear Formula: C10H26N4 · 4HCl
Product Type: Chemical
| λ | 1 M in H2O |
| anion traces | sulfate (SO42-): ≤50 mg/kg |
| assay | ≥99.5% (AT) |
| cation traces | Al: ≤5 mg/kg |
| As: ≤0.1 mg/kg | |
| Ba: ≤5 mg/kg | |
| Bi: ≤5 mg/kg | |
| Ca: ≤10 mg/kg | |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤5 mg/kg | |
| K: ≤50 mg/kg | |
| Li: ≤5 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Mo: ≤5 mg/kg | |
| Na: ≤50 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Sr: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| form | powder |
| grade | Molecular Biology |
| impurities | DNases, none detected |
| insoluble matter, passes filter test | |
| phosphatases, none detected | |
| proteases, none detected | |
| RNases, none detected | |
| InChI | 1S/C10H26N4.4ClH/c11-5-3- |
| InChI key | XLDKUDAXZWHPFH-UHFFFAOYSA |
| mp | 310-311 °C (dec.) (lit.) |
| pH | 4.5-7.0 (25 °C, 1 M in H2O) |
| product line | BioUltra |
| Quality Level | 300  |
| SMILES string | Cl.Cl.Cl.Cl.NCCCNCCCCNCCC |
| solubility | H2O: 1 m at 20 °C, clear, colorless to almost colorless |
| UV absorption | λ: 260 nm Amax: 0.2 |
| λ: 280 nm Amax: 0.15 |
| Application: | Used to precipitate DNA from low salt aqueous buffers. |
| Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Other Notes: | Spermine precipitation of DNA. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.5% (AT) |
| mp | 310-311 °C (dec.) (lit.) |
| UNSPSC | 12352116 |