Spermine
SIGMA/85590 - ≥99.0% (GC)
Synonym: N,N′-Bis(3-aminopropyl)-1,4-diaminobutane; Gerontine; Musculamine; Neuridine
CAS Number: 71-44-3
Empirical Formula (Hill Notation): C10H26N4
Molecular Weight: 202.34
EC Number: 200-754-2
MDL Number: MFCD00008215
Linear Formula: NH2(CH2)3NH(CH2)4NH(CH2)3NH2
Product Type: Chemical
| anion traces | carbonate (CO32-): ≤5000 mg/kg |
| assay | ≥99.0% (GC) |
| biological source | microbial |
| synthetic | |
| bp | 150 °C/5 mmHg (lit.) |
| form | crystalline (chunks) |
| impurities | ≤0.5% spermidine |
| InChI | 1S/C10H26N4/c11-5-3-9-13- |
| InChI key | PFNFFQXMRSDOHW-UHFFFAOYSA |
| mp | 28-30 (lit.) |
| Quality Level | 200  |
| SMILES string | [H]N(CCCN)CCCCN([H])CCCN |
| solubility | water: 0.05 g/mL, clear, colorless |
| storage temp. | 2-8°C |
| Application: | Spermine, a polycationic biogenic polyamine derived from spermidine, may be used in a wide variety of biological applications as a supplement or regulatory agent.Used as co-matrix with DHB for MALDI-MS of sialylated glycans in negative ion mode. |
| Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Biochem/physiol Actions: | Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Hazard Codes | C |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3259PSN2 8 / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.0% (GC) |
| bp | 150 °C/5 mmHg (lit.) |
| mp | 28-30 (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352116 |