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Poly(2′-deoxyinosinic-2′-deoxycytidylic acid) sodium salt

SIGMA/81349 - free from low molecular weight nucleotides, lyophilized

Synonym: Poly(dI-dC) sodium salt

CAS Number: 118578-37-3
MDL Number: MFCD00147947
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-81349-500UG 500 µg
 $452.00
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form powder
grade Molecular Biology
mol wt Mr ~2.5 × 106 (broad molecular weight distribution)
  Mr ~2500000
packaging ampule of ≥10 units A260
quality lyophilized
Quality Level 100 
solubility water: 1 mL/vial, clear, colorless
storage temp. −20°C
Application: Poly(2′-deoxyinosinic-2′-deoxycytidylic acid) sodium salt has been used in electrophoretic mobility shift assay (EMSA) of the transcription factor AP-2 Alpha (TFAP2A) and in southwestern blotting of human embryonic kidney cells (HEK293) nuclear extract.
Application: Suitable for
• non-specific blocking agent in EMSA
• evaluation of DNA methyltransferases
• DNA-small molecule or drug interaction studies
Biochem/physiol Actions: Poly(2′-deoxyinosinic-2′-deoxycytidylic acid), poly(dI-dC) is a synthetic DNA substrate. At high salt, Poly(dI-dC) exists in left handed helical conformation and reverts to right-handed form upon decreasing salt. It is used as a non-specific competitor in electrophoretic mobility shift assay (EMSA).
General description: Poly (2′-deoxyinosinic-2′-deoxycytidylic acid) sodium salt is an alternating copolymer that acts as a substrate for DNA methyltransferases.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352106

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