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Phenylmethanesulfonyl fluoride

SIGMA/78830 - ≥99.0% (T)

Synonym: α-Toluenesulfonyl fluoride; Benzylsulfonyl fluoride; PMSF; Phenylmethylsulfonyl fluoride

CAS Number: 329-98-6
Empirical Formula (Hill Notation): C7H7FO2S
Molecular Weight: 174.19
EC Number: 206-350-2
MDL Number: MFCD00007424
Linear Formula: C7H7FO2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-78830-1G 1 g
 $71.80
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45-78830-5G 5 g
 $149.00
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45-78830-25G 25 g
 $590.00
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assay ≥99.0% (T)
biological source synthetic
form powder or crystals
impurities ≤0.2% water
InChI 1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChI key YBYRMVIVWMBXKQ-UHFFFAOYSA-N
mp 92-95 °C
Quality Level 200 
SMILES string FS(=O)(=O)Cc1ccccc1
solubility anhydrous isopropanol: soluble 35 mg/mL, clear to faintly hazy, colorless to faintly yellow (Heating required)
storage temp. room temp
Application: Phenylmethanesulfonyl fluoride has been used as a component in radioimmunoprecipitation buffer for western blot analysis. It has also been used as a component in the RAW264.7 cell lysis buffer for western blotting.
Biochem/physiol Actions: Phenylmethanesulfonyl fluoride has the ability to enhance the stability of plasma lipidome in lipidomic and metabolomic analysis. This serine protease inhibitor reduces the naloxone-precipitated withdrawal jumping behavior in morphine-dependent mice.
Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research 
Other Notes: Specific trypsin and chymotrypsin inhibitor. Less toxic substitute for diisopropylfluorophosphate. Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.
Other Notes: Specific trypsin and chymotrypsin inhibitor; Less toxic substitute for diisopropylfluorophosphate. Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.
Purity ≥99.0% (T)
mp 92-95 °C
Storage Temp. room temp
UNSPSC 12352202

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