Sodium dodecyl sulfate
SIGMA/75746 - ≥99.0% (GC), dust-free pellets
Synonym: Dodecyl sodium sulfate; Dodecyl sulfate sodium salt; Lauryl sulfate sodium salt; SDS; Sodium lauryl sulfate
CAS Number: 151-21-3
Empirical Formula (Hill Notation): C12H25NaO4S
Molecular Weight: 288.38
EC Number: 205-788-1
MDL Number: MFCD00036175
Linear Formula: CH3(CH2)11OSO3Na
Product Type: Chemical
| aggregation number | 62 |
| anion traces | chloride (Cl-): ≤200 mg/kg |
| assay | ≥99.0% (GC) |
| cation traces | Ca: ≤25 mg/kg |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤10 mg/kg | |
| K: ≤200 mg/kg | |
| Mg: ≤20 mg/kg | |
| Mn: ≤5 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| CMC | 7-10 (lit.) |
| density | 1 g/cm3 |
| description | anionic |
| form | rod |
| HLB | 40(lit.) |
| InChI | 1S/C12H26O4S.Na/c1-2-3-4- |
| InChI key | DBMJMQXJHONAFJ-UHFFFAOYSA |
| loss | ≤5% loss on drying |
| mol wt | average mol wt 18,000 |
| mp | 204 - 207 °C (399 - 405 °F) |
| 204-207 °C (lit.) | |
| Quality Level | 200  |
| SMILES string | [Na+].CCCCCCCCCCCCOS([O-] |
| solubility | 130 g/L at 20 °C (68 °F) |
| H2O: 0.1 M at 20 °C, clear, colorless | |
| H2O: soluble 0.29 gm in 10ml, clear, colorless | |
| transition temp | cloud point >100 °C(lit.) |
| Application: | Anionic detergent |
| Application: | Sodium dodecyl sulfate (SDS) has been used: • as a negatively charged surfactant to study its effects on filtration flux and membrane fouling during the microfiltration of the surfactant-stabilized oil emulsion • as a component of plant extraction buffer, and transferring buffer for western blot • as a component of 5× Laemmli sample buffer (5× LB) and 10× SDS running buffer for sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblot |
| Biochem/physiol Actions: | Sodium dodecyl sulfate (SDS) effectively binds to the positively charged and the hydrophobic residues of proteins via sulfate groups and alkyl chains. It functions as a vital detergent in the domain of structural biology and protein folding/unfolding studies. SDS can stimulate the creation of α-helices in a protein structure. It has the ability to promote cooperative unfolding in several proteins including bovine serum albumin (BSA), β-lactoglobulin, α-lactalbumin, and hen egg-white lysozyme structures at elevated concentrations. |
| Features and Benefits: | • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications • Tested for trace levels of Anions and Cations • High-purity product ideal for biochemical research purposes |
| General description: | Sodium dodecyl sulfate (SDS) is an organic sodium salt used as both a detergent and a protein denaturant in biochemical research. Its unique structure includes a long-chain aliphatic group with a negatively charged sulfate, making it an effective agent for denaturing proteins. This property is especially valuable in electrophoresis, a technique used to separate and analyze macromolecules like proteins. SDS, with its negative charge, interacts with proteins and lipids to create micellar structures, aiding in solubilizing and stabilizing these biomolecules. |
| Other Notes: | For additional information on our range of Biochemicals , please complete this form . |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H302 - H315 - H318 - H412 |
| Precautionary statements | P264 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | F,Xn |
| Risk Statements | 11-21/22-37/38-41 |
| Safety Statements | 26-36/37-39 |
| RIDADR | UN1325 - class 4.1 - PG 3 - Flammable solids, organic, n.o.s., H |
| WGK Germany | WGK 2 |
| Flash Point(F) | 338.0 °F |
| Flash Point(C) | 170 °C |
| Purity | ≥99.0% (GC) |
| mp | 204 - 207 °C (399 - 405 °F); 204-207 °C (lit.) |
| Density | 1 g/cm3 |
| UNSPSC | 12161900 |