Naphthol AS-E phosphate
SIGMA/70485 - suitable for histology
Synonym: KG-501
CAS Number: 18228-17-6
Empirical Formula (Hill Notation): C17H13ClNO5P
Molecular Weight: 377.72
EC Number: 242-106-1
MDL Number: MFCD00042718
Linear Formula: C17H13ClNO5P
Product Type: Chemical
| application(s) | histology |
| assay | ≥80% (HPLC) |
| form | powder |
| InChI | 1S/C17H13ClNO5P/c18-13-5- |
| InChI key | RQAQWBFHPMSXKR-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | OP(O)(=O)Oc1cc2ccccc2cc1C |
| storage temp. | 2-8°C |
| Application: | Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP). |
| Biochem/physiol Actions: | Naphthol AS-E phosphate/KG501, a small-molecule antagonist has the ability to prevent cAMP-response element-binding protein (CREB) pathway. It can also interfere with the interaction of Myb-KIX in vitro and block the actions of Myb in vivo. |
| Other Notes: | Histochemical substrate for alkaline phosphatases,KG-501 blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID domain of CREB and KIX domain of CBP (CREB Binding Protein), classic activator-coactivator interaction. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥80% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352204 |