Kaempferol
SIGMA/60010 - ≥97.0% (HPLC)
Synonym: 3,4′,5,7-Tetrahydroxyflavone; 3,5,7-
CAS Number: 520-18-3
Empirical Formula (Hill Notation): C15H10O6
Molecular Weight: 286.24
MDL Number: MFCD00016938
Linear Formula: C15H10O6
Product Type: Chemical
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥97.0% (HPLC) |
| impurities | ≤12% water |
| InChI | 1S/C15H10O6/c16-8-3-1-7(2 |
| InChI key | IYRMWMYZSQPJKC-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Oc1ccc(cc1)C2=C(O)C(=O)c3 |
| Application: | Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range. |
| Application: | Kaempferol has been used: • to test its effect on osteoblast proliferation, migration, and differentiation in mouse pre-osteoblast cell line (MC3T3-E1 cells) • as an antioxidant and a hepatoprotective agent against zearalenone (ZEA)-induced oxidative stress and apoptosis in HEPG2 cells • as a neuroprotective agent against cadmium chloride (CdCl2) induced hippocampal damage and memory deficits in rats • as an anti-inflammatory agent, together with apigenin, for stem-cell therapy on knee osteoarthritic male rats |
| Biochem/physiol Actions: | Kaempferol is hydrophobic in nature due to its diphenylpropane group. It exerts anti-inflammatory actions along with their antioxidant properties and modulates pro-inflammatory enzyme activities. Kaempferol acts as a chemopreventive agent by exerting protective effects on cell viability. It modulates several key elements of cellular signal transduction pathways linked to apoptosis, angiogenesis, metastasis, and inflammation. |
| Biochem/physiol Actions: | Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol. |
| General description: | Kaempferol is a polyphenolic antioxidant abundantly present in vegetables and fruits. It has a diphenylpropane structure. In many plants, it is present as a glycosidic form namely, kaempferol-3-O-glucoside. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Codes | T |
| Risk Statements | 25-68 |
| Safety Statements | 36/37-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97.0% (HPLC) |
| UNSPSC | 12352205 |