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Tn Antigen

SIGMA/53886 - ≥99.0% (TLC)

Synonym: GalNac-α-1-O-serine; O-[2-(Acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-serine

CAS Number: 67262-86-6
Empirical Formula (Hill Notation): C11H20N2O8
Molecular Weight: 308.29
MDL Number: MFCD01863462
Linear Formula: C11H20N2O8
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-53886-1MG 1 mg
 $446.00
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assay ≥99.0% (TLC)
form powder or crystals
InChI 1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
InChI key REDMNGDGDYFZRE-WKWISIMFSA-N
Quality Level 100 
SMILES string CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O
storage temp. −20°C
Biochem/physiol Actions: Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.
General description: Tn antigen is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥99.0% (TLC)
Storage Temp. −20°C
UNSPSC 12352204

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