Hemin

SIGMA/51280 - BioXtra, from Porcine, ≥96.0% (HPLC)

Synonym: Chloro(protoporphyrinato)iron(III); Chlorohemin; Chloroprotoporphyrin IX iron(III); Ferriprotoporphyrin IX chloride; Hemin(chloride)

CAS Number: 16009-13-5
Empirical Formula (Hill Notation): C₃₄H₃₂ClFeN₄O₄
Molecular Weight: 651.94
EC Number: 240-140-1
MDL Number: MFCD00010726
Linear Formula: C₃₄H₃₂ClFeN₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-51280-1G	1 g	$83.70 1/EA	Add To Favorites
45-51280-5G	5 g	$307.00 1/EA	Add To Favorites
45-51280-25G	25 g	$1110.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥96.0% (HPLC)
biological source	Porcine
form	powder or crystals
InChI	1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;
InChI key	BTIJJDXEELBZFS-HXFTUNQESA-K
product line	BioXtra
Quality Level	200
SMILES string	Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C)c(C=C)c(cc1n2)n6[Fe](Cl)n34)c(C=C)c5C
storage temp.	2-8°C
technique(s)	tissue culture: suitable
	transfection: suitable

Application:

Hemin is used for the following applications:
• To study bacterial strains and growth conditions
• Used in short-term colony assays (the culture medium consists of hemin along with other components)
• Cell transfections
It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.

Biochem/physiol Actions:

Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.

Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥96.0% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352202

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