Guanosine 5′-triphosphate sodium salt hydrate

SIGMA/51120 - ≥90% (HPLC)

Synonym: GTP; GTP-Na⁺ hydrate; 5′-GTP-Na₂

CAS Number: 56001-37-7
Empirical Formula (Hill Notation): C₁₀H₁₆N₅O₁₄P₃ · xNa⁺ · yH₂O
Molecular Weight: 523.18 (anhydrous free acid basis)
EC Number: 252-847-2
MDL Number: MFCD00149227
Linear Formula: C₁₀H₁₆N₅O₁₄P₃ · xNa⁺ · yH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-51120-25MG	25 mg	$72.60 1/EA	Add To Favorites
45-51120-100MG	100 mg	$178.00 1/EA	Add To Favorites
45-51120-1G	1 g	$889.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
form	powder
impurities	≤3 mol/mol water (NMR)
InChI	1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;21H2/q;2+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1
InChI key	HPLNHYUZFVUXFJ-ZVQJTLEUSA-L
optical activity	[α]20/D −24±2°, c = 1% in 0.5 M Na₂HPO₄
Quality Level	100
shipped in	wet ice
SMILES string	O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
solubility	water: 50 mg/mL, clear, colorless
storage temp.	−20°C

Application:

Guanosine 5′-triphosphate sodium salt hydrate has been used:• as a component of the internal solution for astrocyte patch-clamp to monitor astrocyte calcium activity from mouse amygdala slices.
• in a solution for channel current recording in cell lines using a voltage-clamp technique.
• to prepare internal recording solution for injectoporation to deliver genes to mechanosensory hair cells.
• promoting the formation of G interface-mediated homodimers of human septin during the analysis of its oligomerization state by analytical size exclusion chromatography (SEC).

General description:

Guanosine 5′-triphosphate (GTP) is a purine trinucleotide. GTP is a substrate for a wide range of G-protein coupled receptor (GPCR) GTPases, as well as cell signaling and cycling-associated guanine nucleotide exchange factors (GEF). See product G3776 for RNA polymerase transcription and DNA or RNA biosynthesis applications.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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