(4S)-4-Hydroxy-L-isoleucine

SIGMA/50118 - from fenugreek seeds, ≥98.0% (TLC)

Synonym: 4-HYDROXYISOLEUCINE; HIL; (2S,3R,4S)-2-Amino-4-hydroxy-3-methylpentanoic acid

CAS Number: 55399-93-4
Empirical Formula (Hill Notation): C₆H₁₃NO₃
Molecular Weight: 147.17
MDL Number: MFCD07357252
Linear Formula: C₆H₁₃NO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-50118-50MG	50 mg	$573.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98.0% (TLC)
biological source	fenugreek seeds
color	white to almost white
form	powder or flakes
InChI	1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5-/m0/s1
InChI key	OSCCDBFHNMXNME-YUPRTTJUSA-N
optical activity	[α]/D +32.5±2.0°, c = 1 in H₂O
Quality Level	100
SMILES string	C[C@H](O)[C@H](C)[C@H](N)C(O)=O
storage temp.	2-8°C

Biochem/physiol Actions:	(4S)-4-Hydroxy-L-isoleucine (HIL) is a non-proteinogenic α amino acid produced by the activity of bacterial isoleucine dioxygenase(s). (2S,3R,4S)-HIL is being studied to understand its insulinotropic (anti-diabetic) and anti-obesity effects.
Biochem/physiol Actions:	4-Hydroxyisoleucine (HIL) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secretion from pancreatic cells. HIL activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity. HIL reduces plasma levels of triglycerides, free fatty acids and cholesterol.
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	296.6 °F
Flash Point(C)	147 °C

Purity	≥98.0% (TLC)
Storage Temp.	2-8°C
UNSPSC	12352209

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