12-Hydroxy-octadecanoicacid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl)

SIGMA/42966

Synonym: HS 15; Macrogol (15)-hydroxystearate; Polyethylene glycol (15)-hydroxystearate; Polyoxyethylated 12-hydroxystearic acid; Solutol^® HS 15

CAS Number: 70142-34-6
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-42966-1KG	1 kg	$393.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

acid value	≤1.0 mg KOH/g
anion traces	<1 ppm (Ethylene Oxide)
	<10 ppm (Dioxane)
application(s)	sample preservation
cation traces	heavy metals: <10 ppm
	Ni: <1 ppm
composition	free macrogoly% (27.0 - 39.0 g/100g (%))
density	1.03 g/cm³ at 60 °C (140 °F)
	1.048 g/cm³ at 20 °C (68 °F)
description	non-ionic
form	paste
hydroxyl value	90‑110 mg KOH/g
ign. residue	(≤ 0.3 g/100g (%))
impurities	acetic acid (≤ 0.5 g/100g (%))
	water (≤ 0.5 g/100g (%))
	≤0.05% acetic acid
	≤0.05% water
	≤1 mg/kg ethylene oxide
	≤1 mg/kg ethylene oxide ((ppm))
	≤1 mg/kg nickel ((ppm))
	≤1 mg/kg nickle
	≤10 mg/kg dioxane
	≤10 mg/kg dioxane ((ppm))
	≤10 mg/kg heavy metals
	≤620 mg/kg Diethylene glycol
	≤620 mg/kg diethylene glycol ((ppm))
	≤620 mg/kg ethylene glycol
	≤620 mg/kg ethylene glycol ((ppm))
	<10 mg/kg heavy metals ((ppm))
InChI	1S/C47H94O19/c48-15-17-53-19-21-55-23-25-57-27-29-59-31-33-61-35-37-63-39-41-65-43-45-66-44-42-64-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-11-7-6-9-13-46(49)12-8-4-2-1-3-5-10-14-47(50)51/h46,48-49H,1-45H2,(H,50,51)
InChI key	CYAMZYIUAHNTBO-UHFFFAOYSA-N
iodine value	≤2.0 g I₂/100 g
mp	25 - 30 °C (77 - 86 °F)
peroxide value	≤3.0 meq/kg
pH	5.0-7.0 (1 g/10 mL in H₂O)
Quality Level	100
saponification value	53‑63 mg KOH/g
SMILES string	C(CCCCC(CCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O)CCCCC(=O)O
solubility	water: 200 g/L at 30 °C (86 °F)

Application:	• 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) has been used: • in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle force • in roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses • to dissolve finerenone for oral application in in vivo-studies
Biochem/physiol Actions:	12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is mainly used as a solubilizer in parenteral and oral formulations. It is preferred for in vitro screening and in vivo efficacy studies of compounds. 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is also used in ophthalmic, macromolecule, suppository, and protein formulations due to its solubilization characteristics and safety profiles. It can form micelles typically ranging from 10-15 nm. 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) can be used to develop micro-emulsion IV formulations.
General description:	12-Hydroxy-octadecanoicacid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl), a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).
Legal Information:	Solutol is a registered trademark of BASF SE
Other Notes:	12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is a non-ionic detergent obtained by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxy stearic acid.
Other Notes:	For additional information on our range of Biochemicals , please complete this form .

Symbol	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P280
Hazard Codes	Xi
Risk Statements	43
Safety Statements	24-37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	521.6 °F
Flash Point(C)	272 °C

mp	25 - 30 °C (77 - 86 °F)
Density	1.048 g/cm³ at 20 °C (68 °F); 1.03 g/cm³ at 60 °C (140 °F)
UNSPSC	12161900

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