Amentoflavone
SIGMA/40584 - ≥98.0% (HPLC)
Synonym: Didemethyl-ginkgetin; I3′,II8-Biapigenin; Tridemethylsciadopitysin
CAS Number: 1617-53-4
Empirical Formula (Hill Notation): C30H18O10
Molecular Weight: 538.46
MDL Number: MFCD00017470
Linear Formula: C30H18O10
Product Type: Chemical
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥98.0% (HPLC) |
| form | solid |
| InChI | 1S/C30H18O10/c31-15-4-1-1 |
| InChI key | YUSWMAULDXZHPY-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Oc1ccc(cc1)C2=CC(=O)c3c(O |
| storage temp. | 2-8°C |
| Application: | Amentoflavone has been used: • as a chemical inhibitor to determine the selective attenuation of p-Cresol glucuronidation in HepaRG cells • as a reference standard for qualitative and quantitative analyses of phenolic compounds of Juniperus foetidissima Willd. and Juniperus sabina L. using reverse phase- high-performance liquid chromatography- diode array detector (RP-HPLC-DAD) • as a reference standard to analyze and standardize the methanol extract process of Juniperus drupacea Labill. phenolic compounds using reverse phase- high-performance liquid chromatography - diode array detector (RP-HPLC-DAD) |
| Biochem/physiol Actions: | Amentoflavone has various pharmacological properties such as antioxidant, anti-diabetic, anti-tumor, anti-senescence, neuroprotective, and cardioprotective activities. |
| Biochem/physiol Actions: | Biflavonoid with anti-inflammatory, anti-viral and cancer chemopreventive activity. Blocks the induction of COX-2 and up-regulates PPAR-γ. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site. |
| Biochem/physiol Actions: | Biflavonoid with anti-inflammatory, anti-viral and cancer chemopreventive activity. It inhibits vascularization of tumors by blocking the activity of angiogenic VEGFs. Blocks the induction of COX-2 and up-regulates PPAR-γ. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site. |
| General description: | Amentoflavone is a naturally occurring polyphenolic biflavonoid found in many plants. Structurally, it has an apigenin dimer which is linked by a C3′-C8′′ covalent bond. |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98.0% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |