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Dansylcadaverine

SIGMA/30432 - BioReagent, suitable for fluorescence, ≥99.0% (HPLC)

Synonym: N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide; N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine; Monodansyl cadaverine

CAS Number: 10121-91-2
Empirical Formula (Hill Notation): C17H25N3O2S
Molecular Weight: 335.46
EC Number: 233-326-9
MDL Number: MFCD00042704
Linear Formula: C17H25N3O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-30432-100MG 100 mg
 $55.90
1/EA		 Add To Favorites
45-30432-1G 1 g
 $281.00
1/EA		 Add To Favorites

 

assay ≥99.0% (HPLC)
fluorescence λex 335 nm; λem 518 nm in methanol
  λex 338 nm; λem 500 nm (Reaction product)
InChI 1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
InChI key MLEBFEHOJICQQS-UHFFFAOYSA-N
mp 137-140 °C
product line BioReagent
Quality Level 100 
SMILES string CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
storage temp. −20°C
suitability suitable for fluorescence
Application: Dansylcadaverine (MDC), an autofluorescent dye, is used to monitor autophagy. MDC accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.
Biochem/physiol Actions: Inhibitor of the fibrin-stabilizing fator; Inhibitor of epidermal growth factor (EGF) internalization; Fluorescent substrate for the assay of transamidating enzymes.
Biochem/physiol Actions: The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.
Other Notes: Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.
Packaging: air sensitive, handled under inert gas
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Purity ≥99.0% (HPLC)
mp 137-140 °C
Storage Temp. −20°C
UNSPSC 12352108

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