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Cloxacillin sodium salt

SIGMA/27555 - ≥95.0% (HPLC)

Synonym: 3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt; Syntarpen sodium salt

CAS Number: 642-78-4
Empirical Formula (Hill Notation): C19H17ClN3NaO5S
Molecular Weight: 457.86
EC Number: 211-390-9
MDL Number: MFCD00063568
Linear Formula: C19H17ClN3NaO5S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-27555-1G-F 1 g
 $71.90
1/EA		 Add To Favorites
45-27555-5G-F 5 g
 $289.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-positive bacteria
assay ≥95.0% (HPLC)
biological source semisynthetic
color white to off-white
form powder or crystals
impurities ≤5% Total impurities (anhydrous)
InChI 1S/C19H18ClN3O5S.Na/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);/q;+1/p-1/t13-,14+,17-;/m1./s1
InChI key SCLZRKVZRBKZCR-SLINCCQESA-M
mode of action cell wall synthesis | interferes
Quality Level 200 
SMILES string [Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O
storage temp. 2-8°C
Application: Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce β-lactamase. It is used to study the role of pH in antibiotic effectiveness and how oxgall, acid, and hydrogen peroxide stress effects the susceptibility of Bifidobacteria.
Biochem/physiol Actions: Cloxacillin interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins. This inhibits the necessary cross-linking and leads to autolysis of the bacteria by autolysins.
General description: Chemical structure: ß-lactam
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95.0% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51102829

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