Sodium cholate hydrate

SIGMA/27029 - ≥97.0% (dried material, NT)

Synonym: 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt; Cholalic acid sodium salt

CAS Number: 206986-87-0
Empirical Formula (Hill Notation): C₂₄H₃₉NaO₅ · xH₂O
Molecular Weight: 430.55 (anhydrous basis)
EC Number: 206-643-5
MDL Number: MFCD00150749
Linear Formula: C₂₄H₃₉NaO₅ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-27029-100G-F	100 g	$228.00 1/EA	Add To Favorites
45-27029-500G-F	500 g	$911.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

aggregation number	2-3
assay	≥97.0% (dried material, NT)
CMC	9-15 mM (20-25°C)
description	anionic
form	powder
HLB	18
InChI	1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1
InChI key	MUVVIYFKOVLQHL-RCVKHMDESA-M
loss	≤5% loss on drying
mol wt	micellar avg mol wt 900-1300
optical activity	[α]/D 26.0 to 34.0°°, c = 2% (solution in purified water, CALCULATED FOR DRIED SUBSTANCE)
Quality Level	200
SMILES string	O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C
solubility	H₂O: 0.1 M
	H₂O: 100 mg/mL

Application:	Optimization in Transdermal Drug Delivery: Applied in the formulation of ultra-elastic nanovesicles, sodium cholate hydrate enhances the bioavailability and anti-inflammatory efficacy of deflazacort, demonstrating its potential in transdermal drug delivery systems, which can be adapted for diagnostic purposes (Ali et al., 2021 ). Nanocarrier Formulations for IVDs: The study utilizes sodium cholate hydrate in the surface modification of bilosomes, serving as a functional and biocompatible nanocarrier for hybrid compounds, a method applicable to the formulation of innovative IVD reagents (Waglewska et al., 2020 ). IVD Reagent Formulation for Skin Delivery: Sodium cholate hydrate is featured in the development of nano-transfersomes for the delivery of antioxidants, showcasing its role in creating skin-applied diagnostic reagents that offer antioxidant and anti-aging effects (Avadhani et al., 2017 ). Sorting and Separation Techniques in Nanotechnology: Demonstrating the affinity-mediated sorting order reversal, sodium cholate hydrate is critical in density gradient ultracentrifugation techniques, highlighting its utility in the precise sorting and preparation of materials for diagnostic assays (Jang et al., 2016 ).
General description:	Sodium cholate hydrate is a bio-surfactant which can be used as a reducing reagent in aqueous solution.
General description:	Sodium cholate hydrate is a non-denaturing, anionic detergent.
Packaging:	100, 500 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97.0% (dried material, NT)
UNSPSC	12161900

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