α-Tocopherol
SIGMA/258024 - ≥95.5%
Synonym: (±)-α-Tocopherol; DL-all-rac-α-Tocopherol; Vitamin E
CAS Number: 10191-41-0
Empirical Formula (Hill Notation): C29H50O2
Molecular Weight: 430.71
EC Number: 233-466-0
MDL Number: MFCD00006848
Linear Formula: C29H50O2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 258024-100G.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 258024-500G.
| application(s) | cell analysis |
| assay | ≥95.5% |
| biological source | synthetic |
| color | yellow to very dark yellow |
| faint brown to brown | |
| density | 0.950 g/mL at 20 °C (lit.) |
| form | liquid |
| InChI | 1S/C29H50O2/c1-20(2)12-9- |
| InChI key | GVJHHUAWPYXKBD-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | CC(C)CCCC(C)CCCC(C)CCCC1( |
| storage temp. | 2-8°C |
| technique(s) | HPLC: suitable |
| Application: | α-Tocopherol has been used: • as a standard to determine its concentration by reverse-phase high-performance liquid chromatography • to study its rescue effects on chlorine dioxide (ClO2) cytotoxicity • to assess its protective effects on acetaminophen (APAP)-mediated liver damage |
| Biochem/physiol Actions: | Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo. |
| General description: | α-Tocopherol is the active form of vitamin E. It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses. α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease. It has antiproliferative effects. It inhibits arsenite-induced damage of human fibroblasts. |
| Packaging: | 5, 100, 500 g in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Purity | ≥95.5% |
| Density | 0.950 g/mL at 20 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352205 |