CD71 (EP232) Rabbit Monoclonal Primary Antibody
SIGMA/171R-1
Synonym: TFR1; TRF; TRFR; Transferrin Receptor 1; p90; transferrin receptor (p90, CD71)
Product Type: Chemical
Immunohistochemistry CD71 (EP232) on bone marrow
| antibody form | culture supernatant |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | EP232, monoclonal |
| conjugate | unconjugated |
| control | bone marrow |
| description | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| form | buffered aqueous solution |
| isotype | IgG |
| manufacturer/tradename | Cell Marque™ |
| packaging | vial of 0.1 mL concentrate (171R-14) |
| vial of 0.1 mL concentrate Research Use Only (171R-14-RUO) | |
| vial of 0.5 mL concentrate (171R-15) | |
| vial of 1.0 mL concentrate (171R-16) | |
| vial of 1.0 mL concentrate Research Use Only (171R-16-RUO) | |
| vial of 1.0 mL pre-dilute Research Use Only (171R-17-RUO) | |
| vial of 1.0 mL predilute ready-to-use (171R-17) | |
| vial of 7.0 mL pre-dilute ready-to-use Research Use Only (171R-18-RUO) | |
| vial of 7.0 mL predilute ready-to-use (171R-18) | |
| Quality Level | 100  |
| 500 |
|
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated) |
| visualization | cytoplasmic, membranous |
| General description: | Transferrin receptor 1 (CD71) is expressed on placental syncytiotrophoblasts, myocytes, basal keratinocytes, hepatocytes, endocrine pancreas, spermatocytes, and erythroid precursors. The level of transferrin receptor expression is highest in early erythroid precursors through the intermediate normoblast phase, after which expression decreases through the reticulocyte phase. The maturation of erythrocytes results in loss of transferrin receptor expression. AntiCD71 is useful in identifying erythroid precursors. The high level of transferrin receptor within erythroid precursors makes anti-CD71 an excellent marker for evaluation of erythroid precursors within bone marrow biopsy specimens and shows the following features: 1) distinct membranous and cytoplasmic staining pattern, which is easily recognized in bone marrow biopsy; 2) restriction to erythroid lineage within bone marrow biopsy specimens; 3) CD71 expression decreases with the maturation of erythrocytes, with the highest level seen in early forms and the lowest level in late normoblast stage, and most importantly; 4) mature erythrocytes do not express CD71. |
| Legal Information: | Cell Marque is a trademark of Sigma-Aldrich Co. LLC |
| Linkage: | CD71 Positive Control Slides, Product No. 171S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). |
| Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com |
| Physical form: | Predilute: diluted in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide Concentrate: diluted in Phosphate Buffered Saline, pH 7.2, with 1% BSA and <0.1% Sodium Azide |
| Preparation Note: | Download the IFU specific to your product lot and format  Note: This requires a keycode which can be found on your packaging or product label. Download the latest released IFU Note: This IFU may not apply to your specific product lot. |
| Quality: | United States - IVD Canada - IVD European Union - IVD Japan - RUO |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |