CD23 (EP75) Rabbit Monoclonal Primary Antibody
SIGMA/123R-2
Product Type: Chemical
Immunohistochemistry CD23 (EP75) on small lymphocytic lymphoma
| antibody form | culture supernatant |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | EP75, monoclonal |
| conjugate | unconjugated |
| control | chronic lymphocytic leukemia, lymph node, small lymphocytic lymphoma, tonsil |
| description | For In Vitro Diagnostic Use in Select Regions |
| form | buffered aqueous solution |
| isotype | IgG |
| manufacturer/tradename | Cell Marque™ |
| packaging | vial of 0.1 mL concentrate (123R-24) |
| vial of 0.1 mL concentrate Research Use Only (123R-24-RUO) | |
| vial of 0.5 mL concentrate (123R-25) | |
| vial of 1.0 mL concentrate (123R-26) | |
| vial of 1.0 mL concentrate Research Use Only (123R-26-RUO) | |
| vial of 1.0 mL pre-dilute ready-to-use (123R-27) | |
| vial of 1.0 mL pre-dilute Research Use Only (123R-27-RUO) | |
| vial of 7.0 mL pre-dilute ready-to-use (123R-28) | |
| vial of 7.0 mL pre-dilute ready-to-use Research Use Only (123R-28-RUO) | |
| Quality Level | 100  |
| 500 |
|
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated) |
| visualization | membranous |
| General description: | CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas. Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL). |
| Legal Information: | Cell Marque is a trademark of Sigma-Aldrich Co. LLC |
| Linkage: | CD23 Positive Control Slides, Product No. 123S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). |
| Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com |
| Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide. |
| Preparation Note: | Download the IFU specific to your product lot and format  Note: This requires a keycode which can be found on your packaging or product label. Download the latest released IFU Note: This IFU may not apply to your specific product lot. |
| Quality: | United States - IVD Canada - IVD European Union - RUO Japan - RUO |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |