Bafilomycin B1 from Streptomyces sp.

SIGMA/11707 - ≥80% (HPLC)

Synonym: Setamycin

CAS Number: 88899-56-3
Empirical Formula (Hill Notation): C₄₄H₆₅NO₁₃
Molecular Weight: 815.99
Linear Formula: C₄₄H₆₅NO₁₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-11707-1MG	1 mg	$0.00 1/EA CALL FOR PRICE		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	Gram-positive bacteria
assay	≥80% (HPLC)
color	white to yellow
form	powder or crystals
InChI	1S/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48)/b14-12-,18-17+,24-13+,25-20+,34-21-/t26-,27+,28-,29-,30-,33-,35+,39-,40+,41+,42+,44+/m0/s1
InChI key	KFUFLYSBMNNJTF-HHZDOKBSSA-N
mode of action	enzyme \| inhibits
Quality Level	200
shipped in	wet ice
SMILES string	CO[C@H]1C=CC=C(C)C[C@H](C)[C@H](O)[C@H](C)C=C(C)C=C(OC)C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)C=CC(=O)NC3=C(O)CCC3=O)[C@H](C)[C@H](O2)C(C)C
storage temp.	−20°C

Application:	Bafilomycin B1 is a toxic macrolide antibiotic used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis .
Biochem/physiol Actions:	Bafilomycin B1 inhibits vacuolar type H⁺-ATPase (V-ATPase) and is used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis.
Biochem/physiol Actions:	Bafilomycin B1 inhibits vacuolar type H⁺-ATPase (V-ATPase). Bafilomycin B1′s activity results from the presence of a large macrocyclic lactone ring to which deoxy sugars may attach.
General description:	Chemical structure: macrolide
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Moisture sensitive. Keep in a dry place.
Packaging:	1MG
Warning:	Fatal if swallowed. Bafilomycin B1 is fatal if it is inhaled, swallowed, or if it comes in contact with skin.

Symbol	GHS06
Signal word	Danger
Hazard statements	H300 + H310 + H330
Precautionary statements	P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
Hazard Codes	T+
Risk Statements	26/27/28
Safety Statements	36/37/39-45
RIDADR	UN 3462 6.1 / PGI
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥80% (HPLC)
Storage Temp.	−20°C
UNSPSC	51101500

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