K-252a

SIGMA/05288 - from Nocardiopsis sp.

Synonym: Protein kinase inhibitor

CAS Number: 99533-80-9
Empirical Formula (Hill Notation): C₂₇H₂₁N₃O₅
Molecular Weight: 467.47
MDL Number: MFCD00161522
Linear Formula: C₂₇H₂₁N₃O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-05288-100UG-F	100 µg	$171.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	viruses
biological source	Nocardiopsis sp.
form	powder
InChI	1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
InChI key	KOZFSFOOLUUIGY-SOLYNIJKSA-N
mode of action	enzyme \| inhibits
Quality Level	100
SMILES string	[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
storage temp.	−20°C

Application:	K-252a is used to inhibit protein kinases involved in cell signaling processes, including CaM kinase; phosphorylase kinase, serine/threonine kinases, Trk. It is used to inhibit the actions of nerve growth factor (NGF) on PC1 2 cells and to inhibit smooth muscle myosin light chain kinase .
Biochem/physiol Actions:	Potent inhibitor of various protein kinases including protein kinase A, C, and G. It is is reported to selectively inhibit the actions of nerve growth factor (NGF) on PC1 2 cells and has been shown to inhibit smooth muscle myosin light chain kinase .

Symbol	GHS08
Signal word	Danger
Hazard statements	H360D - H371
Precautionary statements	P202 - P260 - P264 - P270 - P280 - P308 + P311
Hazard Codes	T
Risk Statements	61-20/21/22-68/20/21/22
Safety Statements	53-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	51101500

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.