L-Alanine
SIGMA/05130 - ≥99.0% (NT)
Synonym: (S)-2-Aminopropionic acid; L-α-Aminopropionic acid
CAS Number: 56-41-7
Empirical Formula (Hill Notation): C3H7NO2
Molecular Weight: 89.09
EC Number: 200-273-8
MDL Number: MFCD00064410
Linear Formula: C3H7NO2
Product Type: Chemical
| anion traces | chloride (Cl-): ≤50 mg/kg |
| sulfate (SO42-): ≤50 mg/kg | |
| application(s) | detection peptide synthesis |
| assay | ≥99.0% (NT) |
| cation traces | Ca: ≤10 mg/kg |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤5 mg/kg | |
| K: ≤50 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Na: ≤50 mg/kg | |
| NH4+: ≤100 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| color | colorless to white |
| form | powder or crystals |
| ign. residue | ≤0.1% (as SO4) |
| impurities | ≤0.3% foreign amino acids |
| InChI | 1S/C3H7NO2/c1-2(4)3(5)6/h |
| InChI key | QNAYBMKLOCPYGJ-REOHCLBHSA |
| loss | ≤0.1% loss on drying, 110 °C |
| mp | 314.5 °C |
| optical activity | [α]20/D +14.0±1°, c = 5% in 5 M HCl |
| Quality Level | 200  |
| SMILES string | C[C@H](N)C(O)=O |
| solubility | diethyl ether: insoluble |
| ethanol: soluble (cold 80%) | |
| H2O: soluble 89.1 g/l at 20 degrees c |
| Application: | L-Alanine is used as a standard to determine absolute concentration of a protein within a mixture of other proteins measured with SI traceability. |
| Biochem/physiol Actions: | Alanine is a nonessential amino acid that plays a key role in the glucose-alanine cycle between muscle tissue and the liver. In amino acid-degrading tissues such as muscle, amino groups are pooled as glutamate by transamination reactions. The amino group of glutamate is transferred to pyruvate via alanine aminotransferase, forming alanine and α-ketoglutarate. The alanine is passed into the blood and transported to the liver. This reaction is reversed in the liver where pyruvate can be used in gluconeogenesis to form glucose, which may return to other tissues through the circulatory system. Increased alanine levels correlate with higher blood pressure, energy intake, cholesterol levels, and body mass index. |
| Biochem/physiol Actions: | L-alanine has the ability to promote the expression of ferritin and antioxidant stress proteins, heme oxygenase-1 (HO-1). |
| Other Notes: | Preparation of 2-chloropropionic acid; Reduction of derivatives to the aldehyde |
| Preparation Note: | L-Alanine completely dissolves in water at a concentration of 89.1 g/l at 20°C to yield solution. It is also soluble in 80% ethanol and insoluble in ether. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.0% (NT) |
| mp | 314.5 °C |
| UNSPSC | 12352209 |