N-Ethylmaleimide
SIGMA/04260 - purum p.a., ≥99.0% (HPLC)
Synonym: NEM
CAS Number: 128-53-0
Empirical Formula (Hill Notation): C6H7NO2
Molecular Weight: 125.13
EC Number: 204-892-4
MDL Number: MFCD00005509
Linear Formula: C6H7NO2
Product Type: Chemical
| anion traces | chloride (Cl-): ≤50 mg/kg |
| sulfate (SO42-): ≤100 mg/kg | |
| assay | ≥99.0% (HPLC) |
| bp | 210 °C (lit.) |
| cation traces | Ca: ≤50 mg/kg |
| Cd: ≤50 mg/kg | |
| Co: ≤50 mg/kg | |
| Cu: ≤50 mg/kg | |
| Fe: ≤50 mg/kg | |
| K: ≤100 mg/kg | |
| Na: ≤100 mg/kg | |
| Ni: ≤50 mg/kg | |
| Pb: ≤50 mg/kg | |
| Zn: ≤50 mg/kg | |
| grade | purum p.a. |
| ign. residue | ≤0.05% |
| InChI | 1S/C6H7NO2/c1-2-7-5(8)3-4 |
| InChI key | HDFGOPSGAURCEO-UHFFFAOYSA |
| mp | 43-46 °C |
| 43-46 °C (lit.) | |
| Quality Level | 200  |
| SMILES string | CCN1C(=O)C=CC1=O |
| storage temp. | 2-8°C |
| Application: | N-Ethylmaleimide has been used to measure low molecular weight thiols bound to plasma proteins. |
| Application: | Reagent for the covalent modification of cysteine residues in proteins. |
| Biochem/physiol Actions: | Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels. |
| Biochem/physiol Actions: | Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases. |
| Symbol |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H300 - H311 - H314 - H317 |
| Precautionary statements | P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | T+ |
| Risk Statements | 21-28-34-43 |
| Safety Statements | 26-28-36/37/39-45 |
| RIDADR | UN 2928 8(6.1) / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | 163.2 °F |
| Flash Point(C) | 72.9 °C |
| Purity | ≥99.0% (HPLC) |
| bp | 210 °C (lit.) |
| mp | 43-46 °C (lit.); 43-46 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352209 |