Cycloheximide

SIGMA/01810 - ≥95% (HPLC)

Synonym: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide; Actidione; Naramycin A

CAS Number: 66-81-9
Empirical Formula (Hill Notation): C₁₅H₂₃NO₄
Molecular Weight: 281.35
EC Number: 200-636-0
MDL Number: MFCD00082346
Linear Formula: C₁₅H₂₃NO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-01810-1G	1 g	$83.10 1/EA	Add To Favorites
45-01810-5G	5 g	$217.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	yeast
assay	≥95% (HPLC)
biological source	microbial
color	white to light beige
form	powder or crystals
InChI	1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key	YPHMISFOHDHNIV-FSZOTQKASA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	N1C(=O)CC(CC1=O)C[C@@H](O)[C@@H]2C[C@H](C[C@@H](C2=O)C)C

Application:	Cyclohexamide (CHX) is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins, super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques, activate cumulus-free equine oocytes, and to have neuroprotective properties.
Biochem/physiol Actions:	Cyclohexamide inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome.
Biochem/physiol Actions:	Cycloheximide (CHX) is an antibiotic produced by Strptomyces sp.. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
Other Notes:	Conditions for safe storage, including any incompatibilities. Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Packaging:	1G, 5G

Symbol	GHS06,GHS08,GHS09
Signal word	Danger
Hazard statements	H300 - H341 - H360D - H411
Precautionary statements	P201 - P273 - P301 + P310 + P330
Hazard Codes	T+,N
Risk Statements	61-28-38-51/53-68
Safety Statements	53-45-61
RIDADR	UN2811 - class 6.1 - PG 2 - EHS - Toxic solids, organic, n.o.s.,
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
UNSPSC	51102829

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