Trifluoroacetic acid
SIGALD/91707 - puriss. p.a., suitable for HPLC, ≥99.0% (GC)
Synonym: TFA
CAS Number: 76-05-1
Empirical Formula (Hill Notation): C2HF3O2
Molecular Weight: 114.02
EC Number: 200-929-3
MDL Number: MFCD00004169
Linear Formula: CF3COOH
Product Type: Chemical
| λ | 1 cm path, H2O reference |
| assay | ≥99.0% (GC) |
| bp | 72.4 °C (lit.) |
| density | 1.489 g/mL at 20 °C (lit.) |
| form | liquid |
| grade | puriss. p.a. |
| impurities | ≤0.05% water |
| InChI | 1S/C2HF3O2/c3-2(4,5)1(6)7 |
| InChI key | DTQVDTLACAAQTR-UHFFFAOYSA |
| mp | −15.4 °C (lit.) |
| pH | 1 (20 °C, 1 g/L) |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | OC(C(F)(F)F)=O |
| solubility | water: soluble |
| suitability | corresponds to standard for RP gradient test |
| technique(s) | HPLC: suitable |
| LC/MS: suitable | |
| UV absorption | λ: 260 nm Amax: 0.9 |
| λ: 270 nm Amax: 0.1 | |
| λ: 280 nm Amax: 0.08 | |
| λ: 290 nm Amax: 0.07 | |
| λ: 300 nm Amax: 0.06 | |
| λ: 320 nm Amax: 0.05 | |
| vapor density | 3.9 (vs air) |
| vapor pressure | 97.5 mmHg ( 20 °C) |
| Application: | Trifluoroacetic acid (TFA) may be used in the following studies: • Preparation of TFA reagent for the estimation of serum vitamin A. • To compose the binary solvent system for the isolation of large denatured peptides by reverse phase high performance liquid chromatography. • A mobile-phase additive for liquid chromatography-mass spectrometry (LC-MS) analysis. • Preparation of artemisinin under optimized reaction conditions. |
| General description: | Trifluoroacetic acid (TFA) is a fluorinated acetic acid. It is widely used as trifluoromethylating reagent for trifluoromethylation of aromatic compounds. |
| Packaging: | package with 10x1mL |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H314 - H332 - H412 |
| Precautionary statements | P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | C |
| Risk Statements | 20-35-52/53 |
| Safety Statements | 9-26-27-28-45-61 |
| RIDADR | UN 2699 8 / PGI |
| WGK Germany | WGK 2 |
| Flash Point(F) | > 212.0 °F - Pensky-Martens |
| Flash Point(C) | > 100 °C - Pensky-Martens c |
| Purity | ≥99.0% (GC) |
| bp | 72.4 °C (lit.) |
| mp | −15.4 °C (lit.) |
| Density | 1.489 g/mL at 20 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12352106 |