Tetrahydrofuran
SIGALD/178810 - ≥99.0%, contains 200-400 ppm BHT as inhibitor, ReagentPlus®
Synonym: THF; Butylene oxide; Oxolane; Tetramethylene oxide
CAS Number: 109-99-9
Empirical Formula (Hill Notation): C4H8O
Molecular Weight: 72.11
EC Number: 203-726-8
MDL Number: MFCD00005356
Linear Formula: C4H8O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 178810-1L.
| assay | ≥99.0% |
| autoignition temp. | 610 °F |
| bp | 65-67 °C (lit.) |
| contains | 200-400 ppm BHT as inhibitor |
| density | 0.889 g/mL at 25 °C (lit.) |
| dilution | (for general lab use) |
| expl. lim. | 1.8-11.8 % |
| form | liquid |
| InChI | 1S/C4H8O/c1-2-4-5-3-1/h1- |
| InChI key | WYURNTSHIVDZCO-UHFFFAOYSA |
| mp | −108 °C (lit.) |
| pH | ~7 |
| product line | ReagentPlus® |
| Quality Level | 100  |
| refractive index | n |
| SMILES string | C1CCOC1 |
| vapor density | 2.5 (vs air) |
| vapor pressure | 114 mmHg ( 15 °C) |
| 143 mmHg ( 20 °C) |
| Application: | Tetrahydrofuran may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds and acrylate-terminated poly(5-amino-1-pentanol-c |
| General description: | Tetrahydrofuran (THF) is a saturated cyclic ether mainly used as an organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. THF constitutes the key fragment of various natural products (polyether antibiotics). THF can form a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1,4-diol is formed as an intermediate during the synthesis of THF. Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV). |
| Legal Information: | ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | For information on tetrahydrofuran miscibility, please visit the following link: Tetrahydrofuran Miscibility/Immiscibility Table  Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (155810 ) and Cyclopentyl methyl ether (675989 )Read more about THF alternatives: 2-Methyltetrahydroun (2-MeTHF): A biomass-Derived solvent with Broad Applications in Organic Chemistry The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent |
| Packaging: | 1, 4 L in glass bottle |
| Packaging: | 18 L in steel drum |
| Symbol |    GHS02,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H225 - H302 - H319 - H335 - H336 - H351 |
| Precautionary statements | P201 - P202 - P210 - P301 + P312 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | F,Xn |
| Risk Statements | 11-19-36/37-40 |
| Safety Statements | 13-16-29-33-36-37-46 |
| RIDADR | UN 2056 3 / PGII |
| WGK Germany | WGK 1 |
| Flash Point(F) | -6.2 °F - closed cup |
| Flash Point(C) | -21.2 °C - closed cup |
| Supplemental Hazard Statements | EUH018 - EUH019 |
| Purity | ≥99.0% |
| bp | 65-67 °C (lit.) |
| mp | −108 °C (lit.) |
| Density | 0.889 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12191501 |