Octreotide Acetate

SIAL/PHR1880 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Octreotide acetate salt

CAS Number: 79517-01-4
Empirical Formula (Hill Notation): C₄₉H₆₆N₁₀O₁₀S₂ · xC₂H₄O₂
Molecular Weight: 1019.24 (free base basis)
Linear Formula: C₄₉H₆₆N₁₀O₁₀S₂ · xC₂H₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PHR1880-10MG	10 mg	$368.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to USP 1477604
API family	octreotide
application(s)	pharmaceutical
CofA	current certificate can be downloaded
form	powder
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C49H66N10O10S2.2C2H4O2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41;21-2(3)4/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64);21H3,(H,3,4)/t28-,29?,34?,36?,37?,38?,39-,40?,41?,42?;;/m1../s1
InChI key	QWFYIFWTVZFPRY-AARKYNAGSA-N
packaging	pkg of 10 mg
Quality Level	300
SMILES string	S1SCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1)C(=O)N[C@@H]([C@H](O)C)CO)C(O)C)CCCCN)Cc4c5c([nH]c4)cccc5)Cc3ccccc3)NC(=O)C(N)Cc2ccccc2.OC(=O)C.OC(=O)C
storage temp.	-10 to -25°C

Analysis Note:	These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Application:	This pharmaceutical secondary standard can also be used as follows:• Octreotide acetate analysis of amino acids including hydrolysis, derivatization of released amino acids with 4-N,N-dimethylaminoazobenzene-4ʹ-sulfonyl chloride (DABS-Cl), and finally their reversed phase-high performance liquid chromatography (RP-HPLC) determination • Development of a quantitative nuclear magnetic resonance (1H-qNMR) based method for the estimation of octreotide acetate in bulk drug • Determination of octreotide acetate in pharmaceutical formulations using a stability-indicating capillary zone electrophoresis method (CZE) • Estimation of octreotide acetate from a peptide-based hydrogel using an ultra-high performance liquid chromatographic method in combination with photo-diode array detection (PDA), following the quality-by-design (QbD) approach
General description:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Octreotide belongs to the group of synthetic cyclic octapeptides, known for its selectivity towards inhibiting the growth hormone. It binds to the somatostatin receptor 2 (SSTR2), and thereby prevents the secretion pathways of growth hormone. Hence it is used in the treatment of diseases caused by overproduction of growth hormone, such as acromegaly.
Other Notes:	To see an example of a Certificate of Analysis for this material enter LRAC3014 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	-10 to -25°C
UNSPSC	41116107

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