ProClin™ Variety Kit
SIAL/48119-U
Product Type: Chemical
ProClin preservatives attack the central metabolic cycle of the cell, the Krebs cycle, at three specific enzymatic sites: alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, and NADH dehydrogenase. Other inhibited enzymes include pyruvate dehydrogenase, which is vital for oxidation of pyruvate to acetyl-CoA; as well as lactate dehydrogenase and alcohol dehydrogenase, which detoxify waste byproducts synthesized during fermentation. With cellular metabolism debilitated, microorganisms rapidly lose their ability to produce ATP and carry on vital functions, such as transcription, translation and damage repair. All bacteria and fungi possess at least some parts of the Krebs cycle, thus ProClin preservatives represent a highly efficient broad spectrum biocide.
| packaging | pkg of 4 × 5 mL each (includes ProClin 150, 200, 300, and 950) |
| Quality Level | 100  |
| Application: | ProClin preservatives are immediately biocidal upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high levels of resistance, making ProClin highly efficient even over extended storage periods of your IVD components. |
| Legal Information: | ProClin is a trademark of The Dow Chemical Company or an affiliated company of Dow |
| Linkage: | For additional technical details on ProClin, including key features and mechanism of action, please visit www.sigmaaldrich.com/proc. |
| Symbol |     GHS05,GHS07,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H302 + H332 - H314 - H317 - H334 - H335 - H410 |
| Precautionary statements | P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | C,N |
| Risk Statements | 20/21/22-35-37-43-50/53 |
| Safety Statements | 26-36/37/39-45-61 |
| RIDADR | UN 3316 9 |
| WGK Germany | WGK 3 |
| Flash Point(F) | 244.4 °F - closed cup |
| Flash Point(C) | 118 °C - closed cup |
| Supplemental Hazard Statements | EUH071 |
| UNSPSC | 12352201 |
| Components | ProClin 150 5 mL; ProClin 200 5 mL; ProClin 300 5 mL; ProClin 950 5 mL |