Chloramphenicol palmitate
SIAL/46109 - VETRANAL®, analytical standard
CAS Number: 530-43-8
Empirical Formula (Hill Notation): C27H42Cl2N2O6
Molecular Weight: 561.54
EC Number: 208-477-9
MDL Number: MFCD00083597
Linear Formula: C27H42Cl2N2O6
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 46109-100MG
| application(s) | clinical testing |
| format | neat |
| grade | analytical standard |
| InChI | 1S/C27H42Cl2N2O6/c1-2-3-4 |
| InChI key | PXKHGMGELZGJQE-ILBGXUMGSA |
| product line | VETRANAL® |
| shelf life | limited shelf life, expiry date on the label |
| SMILES string | CCCCCCCCCCCCCCCC(=O)OC[C@ |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable | |
| solid phase extraction (SPE): suitable |
| Application: | Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. |
| Biochem/physiol Actions: | Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription. Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it. Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes. |
| Caution: | Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol. |
| Legal Information: | VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH |
| Preparation Note: | Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH. |
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H351 |
| Precautionary statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 40 |
| Safety Statements | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| UNSPSC | 41116107 |