Erythromycin
SIAL/45674 - tested according to Ph. Eur.
Synonym: Erythromycinum
CAS Number: 114-07-8
Empirical Formula (Hill Notation): C37H67NO13
Molecular Weight: 733.93
EC Number: 204-040-1
MDL Number: MFCD00084654
Linear Formula: C37H67NO13
Product Type: Chemical
| agency | EPA 1694 |
| tested according to Ph. Eur. | |
| USP/NF | |
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| application(s) | environmental |
| color | white to faint yellow |
| form | solid |
| InChI | 1S/C37H67NO13/c1-14-25-37 |
| InChI key | ULGZDMOVFRHVEP-RWJQBGPGSA |
| mode of action | protein synthesis | interferes |
| Quality Level | 200  |
| SMILES string | CC[C@H]1OC(=O)[C@H](C)[C@ |
| solubility | acetone: freely soluble |
| acetonitrile: freely soluble | |
| alcohol: soluble | |
| amyl acetate: moderately soluble | |
| chloroform: soluble | |
| diethyl ether: soluble | |
| ethyl acetate: freely soluble | |
| H2O: soluble 2 mg/mL |
| Application: | Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro††, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains. |
| Biochem/physiol Actions: | Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex. Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria. |
| Caution: | This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C. |
| General description: | Chemical structure: macrolide |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. |
| Packaging: | 25g |
| Preparation Note: | This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 51101500 |