CHAPS

ROCHE/CHAPS-RO - 98% (from N), suitable for dialysis, solubility: >50% (Aqueous solutions)

Synonym: CHAPS; 3-[(3-cholamidopropyl)dimethyl-ammonio]-1-propane sulfonate; 3-[(3-cholamidopropyl)dimethyl-ammonio]-1-propane sulfonate, zwitterionic; Cholamidopropyl-dimethyl-ammonio]-1-propane sulfonate, 3-3-, zwitterionic; cholamidopropyl-dimethyl-ammonio]-1-propane sulfonate, 3-3-; 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

CAS Number: 75621-03-3
Empirical Formula (Hill Notation): C₃₂H₅₈N₂O₇S
Molecular Weight: 614.88
MDL Number: MFCD00012116
Linear Formula: C₃₂H₅₈N₂O₇S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-10810118001	10 g	$312.00 1/EA	Add To Favorites
45-10810126001	50 g	$1190.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

absorption	<0.06% at 278 nm in water at 1 % (w/v) (Ease of removal: ++ Note:* * Arbitrary scale ranges from ++ to −)
aggregation number	10
assay	98% (from N)
CMC	4 mM
	6 mM (20-25°C)
description	zwitterionic
form	crystals
InChI	1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22?,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1
InChI key	UMCMPZBLKLEWAF-RFCNGIAKSA-N
manufacturer/tradename	Roche
mol wt	614.88 g/mol (anhydrous basis)
	micellar avg mol wt 6150
packaging	pkg of 10 g (10810118001)
	pkg of 50 g (10810126001)
SMILES string	C[C@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
solubility	>50% (Aqueous solutions)
storage temp.	2-8°C
technique(s)	dialysis: suitable
transition temp	cloud point >100 °C

Application:	CHAPS is a nondenaturing zwitterionic detergent for membrane biochemistry. Useful for solubilizing membrane proteins and breaking protein-protein interactions. CHAPS’ small micellar molecular weight (6,150) and high critical micelle concentration (6-10 mM) allow it to be removed from samples by dialysis. It is also suitable for protein solubilization for isoelectric focusing and two-dimensional electrophoresis. CHAPS is commonly used for non-denaturing (without urea) IEF and has been shown to give excellent resolution of some subcellular preparations and plant proteins. Concentrations between 2-4% (w/v) are typically used in an IEF gel.
Application:	Solubilization of membrane proteins. Combines the properties of both the sulfobetaine-type and bile-acid detergents.
General description:	3-[(3-Cholamidopropyl)dimethyl-ammonio]-1-propane sulfonate
Other Notes:	For life science research only. Not for use in diagnostic procedures.
Physical form:	Crystals
Preparation Note:	Working concentration: PAGE: 6.5 to 13 mM Storage conditions (working solution): Do not store in solution, because precipitation may occur.

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H315 - H319
Precautionary statements	P264 - P270 - P280 - P301 + P312 + P330 - P337 + P313 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	98% (from N)
Storage Temp.	2-8°C
UNSPSC	12161900

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