KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4
ALDRICH/KITALYSIS-CN
Synonym: Amination Screening Kit; Buchwald-Hartwig Amination
Product Type: Chemical
KitAlysis™ C-N High-Throughout Screening Kit: catalysts, stir bars, preweighed bases, substrate vials, and ampules
12 × 2 preweighed catalysts with stir bars and cap mat
Anhydrous, degassed solvents
Internal standard
Provided substrate bottles, preweighed bases, and stir bars
Complete KitAlysis™ Screening Platform (some components sold seperately)
| reaction suitability | reaction type: Buchwald-Hartwig Amination |
| reaction type: Buchwald-Hartwig Cross Coupling Reaction | |
| reaction type: Cross Couplings | |
| reagent type: catalyst core: palladium |
|
| storage temp. | room temp |
| Application: | There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks. Two Solvents, Weak Base (Cs2CO3)  Download the experimental excel file here Two Solvents, Strong Base (NaOt-Bu) Download the experimental excel file here One Solvent (Dioxane), Two Bases Download the experimental excel file here One Solvent (DMAc), Two Bases Download the experimental excel file here Each kit contains 4 screening sets that contain the following: Each customizable screening kit contains • 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars • 2 bases (NaOt-Bu and Cs2CO3) • 2 degassed anhydrous solvents (dioxane and DMAc) in ampules • 2 substrate reaction vials with stir bars • 1 internal standard • 4 reaction block replacement films Monitor reaction progress via TLC-MS by following this protocol Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately). |
| Features and Benefits: | • Designed and tested by synthetic chemists • Easily run 24-microscale reaction in parallel • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks |
| General description: | The KitAlysis™ High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process. |
| Legal Information: | KitAlysis is a trademark of Sigma-Aldrich Co. LLC |
| Symbol |      GHS02,GHS05,GHS07,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H251 - H312 + H332 - H314 - H335 - H351 - H360Df - H373 - H410 |
| Precautionary statements | P235 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| RIDADR | UN 3316 9 |
| Flash Point(F) | -4.0 °F - closed cup |
| Flash Point(C) | -20 °C - closed cup |
| Supplemental Hazard Statements | EUH014 - EUH018 - EUH019 |
| Storage Temp. | room temp |
| UNSPSC | 12161503 |
| Components | N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mL; 1,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mL; Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mL; Josiphos SL-J009-1 Pd G3 5 µmol; SPhos Pd G2 5 µmol; RuPhos Pd G2 5 µmol; P(t-Bu)3 Pd G2 5 µmol; BrettPhos Pd G3, 98% 5 µmol; tBuXPhos Pd G3, 98% 5 µmol; CPhos Pd G3, 95% 5 µmol; XantPhos Pd G3, 95% 5 µmol; XPhos Pd G3, 98%, 1:1 MTBE adduct 5 µmol; MorDalphos Pd G3 5 µmol; DavePhos-Pd-G3, 95% 5 µmol; rac-BINAP-Pd-G3, 95% 5 µmol; SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA |