Dimethyl phosphite
ALDRICH/D178454 - 98%
Synonym: Dimethoxyphosphine oxide; Dimethyl hydrogen phosphite; Dimethyl hydrogen phosphonate; Dimethyl phosphonate; Hydrogen dimethyl phosphite
CAS Number: 868-85-9
Empirical Formula (Hill Notation): C2H7O3P
Molecular Weight: 110.05
EC Number: 212-783-8
MDL Number: MFCD00044633
Linear Formula: (CH3O)2P(O)H
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D178454-500G.
| assay | 98% |
| bp | 170-171 °C (lit.) |
| density | 1.2 g/mL at 25 °C (lit.) |
| form | liquid |
| impurities | ≤0.5% trimethyl phosphate |
| ≤1% methyl alcohol | |
| InChI | 1S/C2H7O3P/c1-4-6(3)5-2/h |
| InChI key | HZCDANOFLILNSA-UHFFFAOYSA |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | [H]P(=O)(OC)OC |
| Application: | Dimethyl phosphite is used in the synthesis of α-aminophosphonates, which are medicinally important phosphorus analogs of amino acids, by treating with an amine and an aldehyde or a ketone. It can also be employed in asymmetric hydrophosphonylation of aldehydes to synthesize optically active α-hydroxy phosphonates. |
| Application: | Dimethyl phosphite may be used as an effective alternative to organic tin hydrides as radical reducing agents for organic halides, thionoesters, and isocyanides to form the corresponding hydrocarbons. Radical translocation/cyclization reactions of terminal alkynes to form cyclic phosphonates can also be effectively carried using dimethyl phosphite as a reagent under tin-free condition. |
| Packaging: | 25, 500 g in glass bottle |
| Symbol |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H317 - H341 - H351 - H412 |
| Precautionary statements | P201 - P273 - P280 - P302 + P352 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 40-43-52/53-68 |
| Safety Statements | 36/37-61 |
| RIDADR | UN 3278 6.1 / PGIII |
| WGK Germany | WGK 1 |
| Flash Point(F) | 158.0 °F - closed cup |
| Flash Point(C) | 70 °C - closed cup |
| Purity | 98% |
| bp | 170-171 °C (lit.) |
| Density | 1.2 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12352100 |