Tris(2-carboxyethyl)phosphine hydrochloride

ALDRICH/C4706 - powder

Synonym: TCEP

CAS Number: 51805-45-9
Empirical Formula (Hill Notation): C₉H₁₅O₆P · HCl
Molecular Weight: 286.65
MDL Number: MFCD00145469
Linear Formula: C₉H₁₅O₆P · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C4706-2G	2 g	$120.00 1/EA	Add To Favorites
45-C4706-10G	10 g	$441.00 1/EA	Add To Favorites
45-C4706-50G	50 g	$2190.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C4706-10G

Properties
Descriptions
Safety Info.
Basic Data

color	white
density	1.041 g/cm³ at 25 °C
description	Protect from moisture
form	powder
InChI	1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H
InChI key	PBVAJRFEEOIAGW-UHFFFAOYSA-N
mp	175-177 °C
Quality Level	300
reaction suitability	reagent type: reductant
SMILES string	Cl[H].OC(=O)CCP(CCC(O)=O)CCC(O)=O
solubility	H₂O: 50 mg/mL
storage temp.	2-8°C

Application:	Tris(2-carboxyethyl)phosphine hydrochloride (TCEP. HCl) can be used: • As a reducing agent for the reduction of sulfoxides, sulfonyl chlorides, N-oxides, and azides. It can also be used in azide-alkyne cycloaddition reaction in the presence of a copper catalyst. • To reduce disulfide bonds in various proteins. • As a reagent for the selective reduction of disulfides in water. • To remove ruthenium-derived metathesis catalysts via aqueous washing of a crude reaction mixture when it is basified. • As a reducing agent for the reduction of various alkyl disulfides such as trans-4,5-dihydroxy-1,2-dithiane.
Application:	Water soluble reagent, used for selective reduction of disulfides. More stable than DTT and useful in mass spectrometry applications.
Disclaimer:	Storage conditions:protect from moisture.
General description:	Tris(2-carboxyethyl)phosphine hydrochloride (TCEP.HCl) is a non-volatile solid. It is a strong reducing agent.1 It can be synthesized by the acid hydrolysis of tris(2-cyanoethyl)phosphine in refluxing aqueous HCl.1 It has various biological applications such as in vitro and in vivo reduction of disulfide bonds in various peptides and proteins. TCEP is a useful chelating agent for various heavy metal ions as Zn(II), Cd(II), Pb(II), and Ni(II).
Packaging:	2, 10, 50 g in glass bottle

Symbol	GHS05,GHS05
Signal word	Danger-Danger
Hazard statements	H314 - H314
Precautionary statements	P260 - P280 - P260 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes	C
Risk Statements	34
Safety Statements	26-27-36/37/39
RIDADR	UN 3261 8 / PGII
WGK Germany	WGK 1

mp	175-177 °C
Density	1.041 g/cm³ at 25 °C
Storage Temp.	2-8°C
UNSPSC	12352128

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