SPhos
ALDRICH/638072 - 98%
Synonym: SPhos; 2-
CAS Number: 657408-07-6
Empirical Formula (Hill Notation): C26H35O2P
Molecular Weight: 410.53
MDL Number: MFCD05861611
Linear Formula: C26H35O2P
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 638072-500G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 638072-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 638072-25G
12 Principles of Green Chemistry: Principle 1—Waste Prevention. This product has a smaller environmental footprint through reduction of waste in the manufacturing process.
12 Principles of Green Chemistry: Principle 3—Less Hazardous Chemical Syntheses. This product manufacturing process was designed with lesser toxicity to human health and the environment.
12 Principles of Green Chemistry: Principle 12—Inherently Safer Chemistry for Accident Prevention. This product utilizes safer chemistry to minimize the potential for chemical accidents, including releases, explosions and fires.
| assay | 98% |
| functional group | phosphine |
| greener alternative category | Re-engineered  , |
| greener alternative product characteristics | Waste Prevention Less Hazardous Chemical Syntheses Inherently Safer Chemistry for Accident Prevention Learn more about the Principles of Green Chemistry . |
| greener alternative product score | old score: 10 new score: 1 Find out more about DOZN™ Scoring |
| InChI | 1S/C26H35O2P/c1-27-23-17- |
| InChI key | VNFWTIYUKDMAOP-UHFFFAOYSA |
| mp | 164-166 °C (lit.) |
| Quality Level | 300 |
| reaction suitability | reaction type: Buchwald-Hartwig Cross Coupling Reaction |
| reaction type: Cross Couplings | |
| reaction type: Heck Reaction | |
| reaction type: Hiyama Coupling | |
| reaction type: Negishi Coupling | |
| reaction type: Sonogashira Coupling | |
| reaction type: Stille Coupling | |
| reaction type: Suzuki-Miyaura Coupling | |
| reagent type: ligand reaction type: Buchwald-Hartwig Cross Coupling Reaction |
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| reagent type: ligand reaction type: Heck Reaction |
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| reagent type: ligand reaction type: Kumada Coupling |
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| reagent type: ligand reaction type: Negishi Coupling |
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| reagent type: ligand reaction type: Suzuki-Miyaura Coupling |
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| SMILES string | COc1cccc(OC)c1-c2ccccc2P( |
| sustainability | Greener Alternative Product |
| Application: | Learn more about Buchwald Phosphine Ligands For small scale and high throughput uses, product is also available as ChemBeads (932191 ) |
| Application: | Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls. |
| Application: | SPhos may be used as a ligand in the following processes: • Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborat • Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines. • Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C. |
| Application: | Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation. |
| General description: | SPhos [2-Dicyclohexylphosphino- |
| General description: | We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Less Hazardous Chemical Syntheses” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard. |
| Legal Information: | Usage subject to Patents: US 6307087; EP 1097158; JP 5758844; CA 2336691 |
| Packaging: | 1, 5, 25, 100, 500 g in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 98% |
| mp | 164-166 °C (lit.) |
| UNSPSC | 12352128 |