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Lithium bis(trimethylsilyl)amide solution

ALDRICH/577928 - 1 M in toluene

Synonym: LiHMDS; Hexamethyldisilazane lithium salt

CAS Number: 4039-32-1
Empirical Formula (Hill Notation): C6H18LiNSi2
Molecular Weight: 167.33
MDL Number: MFCD00008261
Linear Formula: [(CH3)3Si]2NLi
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-577928-100ML 100 mL
 $74.60
1/EA		 Add To Favorites
45-577928-800ML 800 mL
 $430.00
1/EA		 Add To Favorites

 

concentration 1 M in toluene
density 0.860 g/mL at 25 °C
InChI 1S/C6H18NSi2.Li/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
InChI key YNESATAKKCNGOF-UHFFFAOYSA-N
Quality Level 200 
SMILES string [Li]N([Si](C)(C)C)[Si](C)(C)C
Application: LiHMDS can be used as a reagent:
•  In the deprotonation and nucleophilic difluoromethylation reactions.
•  To synthesize isoquinoline derivatives by the addition of N-iodosuccinimide (NIS) to the α-benzyl tosylmethyl isocyanides.
•  To prepare arylboronic acid pinacol esters by the reaction of aryl fluorides with bis(pinacolato)diboron via palladium-catalyzed cross-coupling reaction.
Application: Lithium bis(trimethylsilyl)amide is generally used in organic synthesis as a non-nucleophilic strong Brønsted base. It can be used for salt metathesis reaction for the synthesis of cesium bis(trimethylsilyl)amide (CsHMDS) and lithium fluoride by reacting with cesium fluoride.
General description: Lithium bis(trimethylsilyl)amide solution (LiHMDS) is generally used in organic synthesis as a non-nucleophilic strong Bronsted base.
Packaging: 100, 800 mL in Sure/Seal™
Symbol GHS02GHS05GHS07GHS08  GHS02,GHS05,GHS07,GHS08
Signal word Danger
Hazard statements H225 - H251 - H304 - H314 - H336 - H361d - H373 - H412
Precautionary statements P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes F,C
Risk Statements 63-11-14-34-48/20-65-67
Safety Statements 16-26-36/37/39-45-62
RIDADR UN 2924 8(3) / PGII
WGK Germany WGK 2
Flash Point(F) 48.0 °F - closed cup
Flash Point(C) 8.9 °C - closed cup
Supplemental Hazard Statements EUH014
Density 0.860 g/mL at 25 °C
UNSPSC 12352111

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