Chlorotrimethylsilane
ALDRICH/386529 - purified by redistillation, ≥99%
Synonym: TMSCl; TMCS; Trimethylchlorosilane; Trimethylsilyl chloride
CAS Number: 75-77-4
Empirical Formula (Hill Notation): C3H9ClSi
Molecular Weight: 108.64
EC Number: 200-900-5
MDL Number: MFCD00000502
Linear Formula: (CH3)3SiCl
Product Type: Chemical
| assay | ≥99% |
| autoignition temp. | 752 °F |
| bp | 57 °C (lit.) |
| density | 0.856 g/mL at 25 °C (lit.) |
| expl. lim. | 6.4 % |
| form | liquid |
| impurities | <0.1% dichlorodimethylsilane |
| InChI | 1S/C3H9ClSi/c1-5(2,3)4/h1 |
| InChI key | IJOOHPMOJXWVHK-UHFFFAOYSA |
| mp | −40 °C (lit.) |
| purified by | glass distillation |
| redistillation | |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | C[Si](C)(C)Cl |
| vapor density | 3.7 (vs air) |
| vapor pressure | 100 mmHg ( 25 °C) |
| Application: | Chlorotrimethylsilane (TMSCl) can be used as: • A reagent to protect alcohol and amine groups via the formation of trimethylsilyl ethers and trimethylsilyl amines. • A catalyst for the preparation of 1,3-diphenyl-2-propenone derivatives (chalcones) as antimicrobial agents. • A trapping agent for the anions generated during acyloin condensation reaction. • A better alternative catalyst to the toxic mercuric chloride for the activation of samarium (Sm) during the cyclopropanation of both allylic and α-allenic alcohols. • A catalyst in the transesterification of triglycerides with alcohols to form fatty acid alkyl esters. • A reagent along with lithium bromide for the conversion of alcohols to the corresponding bromides. • A reagent in Fischer glycosidation. • A source of acid catalyst in the reductive benzylation reaction using benzaldehyde and Et3SiH. • A reagent to synthesize sodium trimethylsilanethiolate (Me3SiSNa) by reacting with sodium sulfide, which is an odorless alternative method of synthesizing Me3SiSNa from foul-smelling bis(trimethylsilyl)sulfid |
| General description: | Chlorotrimethylsilane is a chloroorganosilane compound mainly used for silylation reactions. |
| Packaging: | 1, 2 L in Sure/Seal™ |
| Packaging: | 25, 100, 4×100 mL in Sure/Seal™ |
| Symbol |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H225 - H301 + H331 - H312 - H314 |
| Precautionary statements | P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | F,C |
| Risk Statements | 11-14-20/21/22-35-37 |
| Safety Statements | 7/9-16-26-36/37/39-45 |
| RIDADR | UN1298 - class 3 - PG 2 - Trimethylchlorosilane |
| WGK Germany | WGK 1 |
| Flash Point(F) | -18.4 °F - closed cup |
| Flash Point(C) | -28 °C - closed cup |
| Supplemental Hazard Statements | EUH014 |
| Purity | ≥99% |
| bp | 57 °C (lit.) |
| mp | −40 °C (lit.) |
| Density | 0.856 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12352302 |