Ethyl chloroformate
ALDRICH/185892 - 97%
Synonym: Chloroformic acid ethyl ester
CAS Number: 541-41-3
Empirical Formula (Hill Notation): C3H5ClO2
Molecular Weight: 108.52
EC Number: 208-778-5
MDL Number: MFCD00000644
Linear Formula: ClCOOC2H5
Product Type: Chemical
| assay | 97% |
| autoignition temp. | 842 °F |
| bp | 93 °C (lit.) |
| density | 1.135 g/mL at 25 °C (lit.) |
| form | liquid |
| functional group | chloro |
| InChI | 1S/C3H5ClO2/c1-2-6-3(4)5/ |
| InChI key | RIFGWPKJUGCATF-UHFFFAOYSA |
| mp | −81 °C (lit.) |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | CCOC(Cl)=O |
| solubility | alcohol: miscible |
| benzene: miscible | |
| chloroform: miscible | |
| diethyl ether: miscible | |
| water: insoluble | |
| vapor density | 3.74 (vs air) |
| vapor pressure | 3.42 psi ( 20 °C) |
| Application: | • Ethyl chloroformate was used in the synthesis of nitrile oxides. • It was used as derivatization reagent to investigate stereochemical conversion of chiral non-steroidal anti-inflammatory drugs during derivatization reaction. • It was used to develop flexible template strategy for the generation of nanometer-scale templates via dip-pen nanolithography. • It was used as derivatization reagent in an enantiomeric analysis of amino acids by two-dimensional gas chromatography. • It was also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles. |
| Packaging: | 100, 500 g in Sure/Seal™ |
| Packaging: | 2 kg in poly bottle |
| Packaging: | 5 g in glass bottle |
| Packaging: | Derivatization reagent employed in an enantiomeric analysis of amino acids by two-dimensional gas chromatography. Also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles. |
| Symbol |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H225 - H290 - H302 - H314 - H330 |
| Precautionary statements | P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | F,T+,N |
| Risk Statements | 11-22-26-34-50 |
| Safety Statements | 9-16-26-28-33-36/37/39-45-61 |
| RIDADR | UN1182 - class 6.1 - PG 1 - Ethyl chloroformate |
| WGK Germany | WGK 1 |
| Flash Point(F) | 60.8 °F |
| Flash Point(C) | 16 °C |
| Purity | 97% |
| bp | 93 °C (lit.) |
| mp | −81 °C (lit.) |
| Density | 1.135 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12352100 |