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6-Hydroxydopamine hydrobromide

ALDRICH/162957 - 95%

Synonym: 2,4,5-Trihydroxyphenethylamine hydrobromide; 2,5-Dihydroxytyramine hydrobromide; 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide; 6-OHDA

CAS Number: 636-00-0
Empirical Formula (Hill Notation): C8H11NO3 · HBr
Molecular Weight: 250.09
EC Number: 211-247-0
MDL Number: MFCD00012894
Linear Formula: (HO)3C6H2CH2CH2NH2 · HBr
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-162957-50MG 50 mg
 $42.70
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45-162957-250MG 250 mg
 $151.00
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45-162957-1G 1 g
 $492.00
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45-162957-5G 5 g
 $1960.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 162957-250MG.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 162957-50MG.

 

assay 95%
form powder
InChI 1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChI key MLACDGUOKDOLGC-UHFFFAOYSA-N
mp 216-220 °C (lit.)
Quality Level 100 
SMILES string Br.NCCc1cc(O)c(O)cc1O
storage temp. −20°C
Application: 6-Hydroxydopamine hydrobromide has been used:
• to induce Parkinson′s disease (PD) in mouse models to study the effects of tubastatin A (TBA) on nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) activation and cell injury in SH-SY5Y cells
• to induce pharmacological ablation of the sympathetic nerves to study the effect of hepatic sympathetic nerve activity (SNA) on hepatic steatosis during diet-induced obesity in mice
• to induce oxidative stress in mesencephalic cells to study its effect on p75NTR signaling in neuronal cells of the ventral mesencephalon
Biochem/physiol Actions: 6-Hydroxydopamine hydrobromide (6-OHDA) is a neurotoxin that elicits oxidative damage and destroys catecholaminergic or sympathetic terminals. It is commonly used to induce Parkinson′s disease in the experimental model. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death.
General description: Solutions should be freshly prepared and protected from exposure to light.
Packaging: 1, 5 g in glass bottle
Packaging: 50, 250 mg in glass insert
Purity 95%
mp 216-220 °C (lit.)
Storage Temp. −20°C
UNSPSC 12352116

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