Anti-HDAC5 (Ab-498) antibody produced in rabbit
SIGMA/SAB4300414 - affinity isolated antibody
Synonym: Anti-FLJ90614 antibody produced in rabbit; Anti-HD5 antibody produced in rabbit; Anti-NY-CO-9 antibody produced in rabbit; Anti-histone deacetylase 5 antibody produced in rabbit
Product Type: Chemical
Immunohistochemistry Anti-HDAC5 (Ab-498): SAB4300414: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-HDAC5 (Ab-498) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunoblotting Anti-HDAC5 (Ab-498): SAB4300414: Analysis of extracts from 293 and HepG2 cells using Anti-HDAC5 (Ab-498) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (T-Q-S-S-P) |
| isotype | IgG |
| mol wt | ~124 kDa |
| NCBI accession no. | NP_001015053.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q9UQL6 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. |
| Immunogen: | Peptide sequence around aa. 496-500 (T-Q-S-S-P), according to the protein HDAC5. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |