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Anti-MR−Pro ADM (Internal) antibody produced in rabbit

SIGMA/SAB4200667 - affinity isolated antibody

Synonym: mid regional pro−ADM

Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SAB4200667-100UL 100 µL
 $514.00
1/EA		 Add To Favorites
Immunohistochemistry Staining of formalin-fixed, paraffin-embedded Human Placenta sections with 20 μg/mL Rabbit Anti-MR-Pro ADM (Internal) (Cat. No. SAB4200666). The antibody was developed using biotin/ExtrAvidin®-Peroxidase.
Immunohistochemistry Staining of formalin-fixed, paraffin-embedded Human Pancease sections with 20 μg/mL Rabbit Anti-MR-Pro ADM (Internal) (Cat. No. SAB4200666). The antibody was developed using biotin/ExtrAvidin®-Peroxidase.
Immunohistochemistry Staining of formalin-fixed, paraffin-embedded Rat Lung sections with 20 μg/mL Rabbit Anti-MR-Pro ADM (Internal) (Cat. No. SAB4200666). The antibody was developed using biotin/ExtrAvidin®-Peroxidase.
Immunoblotting Recombinant human MR-Pro ADM peptide (amino acid 45-92) was separated on SDS-PAGE and probed with Rabbit Anti-MR-Pro ADM (Internal) (Cat. No. SAB4200667). The antibody was developed using Goat Anti-Rabbit IgG-Peroxidase (Cat. No. A0545) and a chemiluminescent substrate. Lanes 1. 0.5 μg/mL antibody 2. 0.25 μg/mL antibody

 

antibody form affinity isolated antibody
antibody product type primary antibodies
biological source rabbit
concentration ~1 mg/mL
form buffered aqueous solution
mol wt ~5 kDa
Quality Level 200 
shipped in dry ice
species reactivity human
storage temp. −20°C
technique(s) immunoblotting: 0.25-0.5 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92)
  immunohistochemistry: 20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas or placenta sections
UniProt accession no. P35318 
Biochem/physiol Actions: In hemodialysis patients increased plasma levels of MR-pro-ADM (mid-regional-pro-adrenomedullin) is linked with decreased survival. This is due to increased vasodilation in response to higher levels of MR-pro-ADM; lower levels of this peptide result in increased vasoconstriction and hence, better prognosis. This peptide is also associated with increased cardiovascular mortality in dialysis patients. In type II diabetic patients, MR-pro-ADM peptide is linked with renal outcome, as adrenomedullin (ADM) gene regualates susceptibility to nephropathic progression.
Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description: MR-pro-ADM (mid-regional-pro-adrenomedullin) is a 47-residue long peptide, produced during posttranslational processing of adrenomedullin. It has a molecular weight of 5.1kDa. Adrenomedullin (ADM) is a vasodilator peptide which is produced and released by a wide variety of cells such as, macrophages, fibroblasts, cardiomyocytes etc. MR-pro-ADM functions as a substitute marker for ADM. This peptide is coded by the gene localized to human chromosome 11p15.4 which is composed of four exons and three introns.
Immunogen: synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM)
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Specificity: Anti-MR-Pro ADM (Internal) recognizes human MR-Pro ADM.
Storage and Stability: For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
RIDADR NONH for all modes of transport
WGK Germany nwg
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 51111800

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