Anti-ATF3 antibody produced in rabbit
SIGMA/HPA001562 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym: ATF3 Antibody - Anti-ATF3 antibody produced in rabbit; Atf3 Antibody; Anti-Activating transcription factor 3 antibody produced in rabbit; Anti-Cyclic AMP-dependent transcription factor ATF-3 antibody produced in rabbit
MDL Number: MFCD01092265
Product Type: Chemical
Immunohistochemistry Immunohistochemical staining of human placenta shows strong nuclear positivity in trophoblastic cells.
Immunohistochemistry Immunohistochemical staining of human fallopian tube shows moderate to strong nuclear positivity in a subset of glandular cells.
Immunohistochemistry Immunohistochemical staining of human urinary bladder shows moderate to strong nuclear positivity in epithelial cells.
Immunohistochemistry Immunohistochemical staining of human skeletal muscle shows no nuclear positivity in myelopoietic cells as expected.
Immunofluorescence Immunofluorescent staining of human cell line A-431 shows localization to nucleus and nucleoli.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| enhanced validation | orthogonal RNAseq Learn more about Antibody Enhanced Validation  |
| form | buffered aqueous glycerol solution |
| immunogen sequence | MMLQHPGQVSASEVSASAIVPCLSP |
| packaging | antibody small pack of 25 μL |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| technique(s) | immunofluorescence: 0.25-2 μg/mL |
| immunohistochemistry: 1:200-1:500 | |
| UniProt accession no. | P18847  |
| Application: | Anti-ATF3 antibody produced in rabbit has been used in: • western blotting • immunofluorescence • immunohistochemical staining • chromatin immunoprecipitation (ChIP) |
| Biochem/physiol Actions: | Activating transcription factor 3 (ATF3), a cyclic AMP-dependent transcription factor stimulates transcription by sequestering inhibitory cofactors. ATF3 responds to stress signals and is involved in the regulation of immune and metabolic homeostasis. It helps to prevent chronic inflammation and starvation responses. ATF3 expression is induced in response to eye injury. It serves as a marker for neuronal injury. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| General description: | Activating transcription factor 3 (ATF3) gene is mapped to human chromosome 1q32.3. The encoded protein belongs to the cAMP-response element binding (CREB) protein family. |
| General description: | Rabbit polyclonal anti-ATF3 antibody reacts with human activating transcription factor 3. |
| Immunogen: | Cyclic AMP-dependent transcription factor ATF-3 recombinant protein epitope signature tag (PrEST) |
| Legal Information: | Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC |
| Linkage: | Corresponding Antigen APREST77475 . |
| Physical form: | Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |