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Penetratin™ 1 Peptide

By MP Biomedicals

Penetratin™ 1 Peptide

Novel tool for gene targeting

  • Internalize peptides and oligonucleotides
  • Low concentrations are required for internalization (1.25 - 20 µM)
  • Internalized with all cell types tested
  • Convey coupled molecules directly to the cytoplasm and nucleus of the cell
  • Simple coupling procedure for peptides and oligonucleotides containing a free thiol group
  • Mild internalization procedure ensures high survival rate compared to other methods

Penetratin™ 1 is a patented 16-amino acid peptide corresponding to the third helix of the homeodomain of antennapedeia protein. This peptide is able to translocate across biological membranes by an energy-independent mechanism and has been used successfully to internalize covalently attached peptides and oligonucleotides and to convey them to the cytoplasm and nucleus of many cell types (1-4). Activated Penetratin™ 1 is sold ready for coupling to peptides or oligos containing thiol (-SH) functions. Biotinylated Activated Penetratin™ 1 possesses a biotin group at the C-terminal end allowing the detection of the internalized molecule with an appropriate avidin or streptavidin reagent.


  • Introduce inhibitory peptides into the nucleus and cytoplasm of cells
  • Introduce pharmacologically active substances into cultured cells
  • Use antisense oligonucleotides or peptide nucleic acids to disrupt gene activity
  • Block receptors in the cell nucleus

Storage: -20°C

Cat.No. Name Size EA    
17-PENA0500 Activated penetratin 1 peptide 500µg $0.00
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17-PENB0500 Biotinylated Activaed penetratin 1 peptide 500µg DISCONTINUED  

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