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Anti-TMEM119 antibody produced in rabbit

SIGMA/HPA051870 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym: Tmem119 Antibody; Tmem119 Antibody - Anti-TMEM119 antibody produced in rabbit; Anti-transmembrane protein 119

Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-HPA051870-25UL 25 µL
$294.00
1/EA
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45-HPA051870-100UL 100 µL
$570.00
1/EA
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Enhanced Validation-By Independent Antibodies Immunohistochemical staining of human cerebral cortex, liver, lymph node and testis using Anti-TMEM119 antibody HPA051870 (A) shows similar protein distribution across tissues to independent antibody HPA052650 (B).
Immunohistochemistry Immunohistochemical staining of human cerebral cortex shows moderate membranous positivity in microglia.
Immunohistochemistry Immunohistochemical staining of human liver shows no positivity in hepatocytes as expected.
Immunohistochemistry Immunohistochemical staining of human lymph node strong positivity in reticular fibers in germinal center cells.
Immunohistochemistry Immunohistochemical staining of human testis shows moderate cytoplasmic positivity in peritubular myoid cells.

 

antibody form affinity isolated antibody
antibody product type primary antibodies
biological source rabbit
clone polyclonal
conjugate unconjugated
enhanced validation independent
orthogonal RNAseq
Learn more about Antibody Enhanced Validation 
form buffered aqueous glycerol solution
immunogen sequence GDGARMVEGRGAEEEEKGSQEGDQEVQGHGVPVETPEAQEEPCSGVLEGAVVAGEGQGELEGSLLLAQEAQGPVGPPESPCACSSVHPS
packaging antibody small pack of 25 μL
product line Prestige Antibodies® Powered by Atlas Antibodies
Quality Level 100 
shipped in wet ice
species reactivity human
storage temp. −20°C
technique(s) immunohistochemistry: 1:500-1:1000
UniProt accession no. Q4V9L6 
Application: Anti-TMEM119 antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions: Transmembrane protein 119 (TMEM119) acts as an osteoinductive factor and facilitates proliferation, migration and invasion of osteosarcoma cells.(28} It is a critical molecule acting downstream of the parathyroid hormone (PTH) and similar to mothers against decapentaplegic-3 (Smad3) signaling pathways in osteoblasts. TMEM119 is considered to be a potential microglial marker that differentiates resident microglia from blood-derived macrophages in the human brain. Mutation in the gene is associated with the development of osteosarcoma.
Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits: Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.
General description: Transmembrane protein 119 (TMEM119) is encoded by the gene mapped to human chromosome 12q23.3. The encoded protein belongs to the transmembrane protein family. TMEM119 has an O-glycosylated N-terminal region.
Immunogen: transmembrane protein 119 recombinant protein epitope signature tag (PrEST)
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC
Linkage: Corresponding Antigen APREST85802 .
Physical form: Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Storage Temp. −20°C
UNSPSC 12352200

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