Type IV Collagen is a ubiquitous component in basement membranes and provides the major structural support for this matrix. When the Collagen IV meshwork is assembled, it provides a scaffold for the assembly of other basement membrane components through interactions with laminin, entactin/nidogen, and heparan sulfate proteoglycan. Collagen IV is useful as a substrate for growth of epithelial, endothelial, muscle, and nerve cells. Collagen plays a role in the regulation of cell growth, differentiation and adhesion, as well as tissue formation.

BD BioCoat™ Collagen IV Cellware offers tissue-culture vessels with a uniform application of mouse collagen type IV.

Applications include:

• Promotion of cell attachment and spreading
• Cell differentiation and neurite outgrowth
• Increased proliferation of PC12 cells
• Studies of effects of Collagen IV on cell behavior
• Cell Adhesion Assays