Collagen I, found in most tissues and organs, is most plentiful in dermis, tendon, and bone. It is an integral part of the framework that holds cells and tissues together and has been recognized as a useful matrix for improving cell culture. In vitro use of collagen can exert effects on the adherence, morphology, growth, migration, and differentiation of a variety of cell types.

BD BioCoat™ Collagen I Cellware offers tissue-culture vessels with a uniform application of rat tail collagen type 1. It improves cell attachment and increases proliferation rates for a variety of normal and transformed mammalian cell types.

Applications include:

• Promotion of cell attachment and spreading
• Rapid expansion of cell populations
• Serum-free or reduced serum culture
• Cell adhesion assay
• Improving survival of primary cells in culture